This course emphasizes the principles of biomolecule-based sensing, including molecular recognition, biomolecular binding kinetics and equilibrium; methods of detection and signal transduction, including optical, colorimetric, fluorescence, potentiometric, and gravimetric techniques; statistical principles of high throughout screening; microfluidic and microarray device design principles and fabrication technologies; molecular motors. Prerequisites: 03-231 OR 03-232 Biochemistry.