This course presents both the theoretical underpinnings of computational methods used in modern molecular biology and practical training in using these methods and the data resources to which they can be applied. It is intended for students without computer programming experience. Topics included are biological sequencing and databases, sequence searching and alignment, protein structure, whole genome resources, genetic variations and their relationship to phenotype, gene and protein expression, and biological networks and pathways. Course work consists primarily of homework assignments making use of online resources for these applications. Students may only use one of the following for credit, 03-310, 03-311, 03-510 or 03-710.